Biological Drug Targets
Explore the molecular receptors, enzymes, ion channels, and immune checkpoints targeted by approved therapeutics and investigational pipeline agents.
SERPINC1
Antithrombin-III is a plasma glycoprotein synthesized primarily in the liver, belonging to the serpin (serine protease inhibitor) superfamily. It circulates in the blood where it acts as a…
Coagulation Factor Xa
Coagulation Factor Xa (FXa) is a serine protease that plays a central role in the coagulation cascade, acting at the convergence of the intrinsic and extrinsic pathways. It…
Dihydrofolate Reductase
Dihydrofolate Reductase (DHFR) is a ubiquitous cytosolic enzyme found in nearly all living cells. It catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate (THF). THF is a crucial…
Dopamine Transporter
The Dopamine Transporter (DAT) is an integral membrane protein predominantly expressed on the presynaptic terminals of dopaminergic neurons throughout the central nervous system. Its primary physiological role involves…
Gamma-aminobutyric acid type A receptor
The Gamma-aminobutyric acid type A (GABA-A) receptor is a pentameric ligand-gated chloride ion channel predominantly located in the neuronal membranes of the central nervous system. Upon binding of…
GRIN1, GRIN2A
The N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel found in the postsynaptic membrane of neurons throughout the central nervous system. This receptor is a heterotetrameric complex typically…
SCN1A, SCN5A, SCN9A
Voltage-gated sodium channels are transmembrane protein complexes primarily localized to the plasma membrane of excitable cells, such as neurons and muscle cells. These channels are composed of a…