5-hydroxytryptamine receptor 1A
Biological Target
5-hydroxytryptamine receptor 1A Description
The 5-HT1A receptor is a G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system, particularly in the hippocampus, limbic system, and raphe nuclei. It functions as an inhibitory autoreceptor on serotonergic neurons and as a postsynaptic receptor on non-serotonergic neurons. Upon activation, it couples to Gi/Go proteins, leading to inhibition of adenylyl cyclase, opening of G protein-gated inwardly rectifying potassium channels, and inhibition of voltage-gated calcium channels, thereby reducing neuronal excitability and modulating mood, anxiety, and cognition.
Medications Targeting 5-hydroxytryptamine receptor 1A
No approved therapeutics or investigational compounds are currently cataloged for this target in our database.