Dopamine D2 Receptor
Biological Target
Dopamine D2 Receptor Description
The Dopamine D2 Receptor is a G protein-coupled receptor primarily located in the brain, particularly in the striatum and substantia nigra. It plays a crucial role in mediating the effects of dopamine, influencing motor control, motivation, reward, and cognition. Activation of D2 receptors generally inhibits adenylyl cyclase activity, leading to decreased intracellular cAMP levels and modulating neuronal excitability.
Medications Targeting Dopamine D2 Receptor
No approved therapeutics or investigational compounds are currently cataloged for this target in our database.