Vasopressin V2 receptor

The Vasopressin V2 receptor is a G protein-coupled receptor primarily expressed on the basolateral membrane of principal cells in the renal collecting ducts. Upon activation by its endogenous ligand, arginine vasopressin, it initiates a signaling cascade that leads to the insertion of aquaporin-2 water channels into the apical membrane. This action increases water permeability and reabsorption, playing a critical role in maintaining body fluid osmolality and concentrating urine.