Gamma-aminobutyric acid type A receptor
Biological Target
Gamma-aminobutyric acid type A receptor Description
The Gamma-aminobutyric acid type A (GABA-A) receptor is a pentameric ligand-gated chloride ion channel predominantly located in the neuronal membranes of the central nervous system. Upon binding of its endogenous ligand, GABA, it mediates the influx of chloride ions, leading to hyperpolarization and inhibition of neuronal excitability. This receptor is critical for regulating inhibitory neurotransmission and maintaining the excitatory-inhibitory balance in the brain.
Medications Targeting Gamma-aminobutyric acid type A receptor
No approved therapeutics or investigational compounds are currently cataloged for this target in our database.