Drug Class Cardiovascular System

VEGF/VEGFR inhibitors

System Cardiovascular System

Organ Blood Vessels

Target Type Receptor

Target Vascular Endothelial Growth Factor Receptor (VEGFR)

Class Overview

VEGF/VEGFR inhibitors are medications that block the activity of vascular endothelial growth factor (VEGF) and its receptor (VEGFR), which are proteins that stimulate the growth of new blood vessels. By inhibiting this process, these drugs help cut off the blood supply that tumors and certain eye conditions need to grow.

Mechanism of Action

These drugs work by preventing VEGF from binding to its receptor on blood vessel cells. This stops the signaling that would normally trigger the formation of new blood vessels (angiogenesis). Without a blood supply, tumors cannot grow or spread, and abnormal blood vessels in the eye can be reduced.

Active Substances in this Class (28)

Acetaminophen Acyclovir Amantadine Apixaban Aripiprazole Aspirin Bupropion Clonidine Dexamethasone Dextroamphetamine / Amphetamine Dextromethorphan Digoxin Empagliflozin Famotidine Folic Acid Heparin Hydroxyurea Ketamine Lithium Metformin Methotrexate Octreotide Phenytoin Sacubitril / Valsartan Semaglutide Sitagliptin Ticagrelor Tranexamic Acid