N-methyl-D-aspartate receptor

Ionotropic Glutamate Receptor — Gene: GRIN1, GRIN2A

                        Target Code:
                        Q05586
                    

Code Q05586

Associated Gene GRIN1, GRIN2A

Target Organ Brain, Central Nervous System, Hippocampus

System Central Nervous System

Target Family Ionotropic Glutamate Receptor

N-methyl-D-aspartate receptor Target Structure

Structure View Full Screen

N-methyl-D-aspartate receptor Description

The N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel found in the postsynaptic membrane of neurons throughout the central nervous system. This receptor is a heterotetrameric complex typically composed of GluN1, GluN2 (A, B, C, or D), and sometimes GluN3 subunits, forming a channel permeable to calcium, sodium, and potassium ions. Its activation by glutamate and co-agonist glycine (or D-serine) is critical for synaptic plasticity, learning, and memory processes.

Medications Targeting N-methyl-D-aspartate receptor

No approved therapeutics or investigational compounds are currently cataloged for this target in our database.