Antithrombin-III

Serine Protease Inhibitor (Serpin) — Gene: SERPINC1

                        Target Code:
                        P01008
                    

Code P01008

Associated Gene SERPINC1

Target Organ Blood Plasma, Liver, Vascular Endothelium

System Hematologic & Cardiovascular System

Target Family Serine Protease Inhibitor (Serpin)

Structure View Full Screen

Antithrombin-III Description

Antithrombin-III is a plasma glycoprotein synthesized primarily in the liver, belonging to the serpin (serine protease inhibitor) superfamily. It circulates in the blood where it acts as a crucial physiological inhibitor of several coagulation proteases. Its primary function is to inactivate thrombin (Factor IIa) and Factor Xa, thereby preventing excessive blood clot formation and maintaining hemostatic balance.

Medications Targeting Antithrombin-III

Heparin → Modulator

Biologic (Glycosaminoglycan macromolecule)

Class: Heparins