How do diuretics work?

Diuretics are a diverse group of medications designed to target the nephron to significantly impact urination. Often referred to casually as “water pills,” these pharmacological agents are the cornerstone of managing conditions ranging from hypertension to heart failure. While the term suggests a simple function—making you pee—the mechanism is a sophisticated biological bio-hack. These drugs … Read more

Pertuzumab Mechanism of Action. New Hope – Old target

Scientists and researchers have their odd ways of solving problems, and when they team up with one of the biggest biotech companies, their ideas can go beyond research papers—and become real-world solutions we get to see. Brief History of Pertuzumab Pertuzumab (Parjeta) is a clear example of a scientific and marketing genius. It entered the … Read more

6 Major Targets for the Medications

Angiotensin receptor and blocker

Have you ever wondered exactly how the medications you take actually work? It’s not magic; it’s molecular biology. Every drug, from a simple over-the-counter painkiller to cutting-edge chemotherapy, must interact with a specific component in your body to produce its therapeutic effect. In pharma science, those biological or chemical structures of your body targeted by … Read more

Bimzelx Mechanism of Action. New mAb to Clear IL-17

Bimzelx, bemakizumab mechanism of action

Bimzelx (Bimekizumab) is a monoclonal antibody, which calms down inflammation in psoriasis and psoriatic arthritis by binding and blocking two pro-inflammatory molecules: Filling two needs with one dead, scientists developed an antibody against a site common for both A and F subtypes of interleukin 17. It allowed bimekizumab to completely shoutdown this signalling molecule from … Read more

Teclistamab Mechanism of Action. Twice more Powerful

I am Taclistamab, designed in the lab,A mighty bi-specific mAb.One end binds cancer, holding it tight,One end finds T-cells to join the fight.I help the immune system take its aim,And snipe myeloma, ending its game. How Taclistamab helps Immune System to fight Myeloma Teclistamab is a new approach of cancer treatment. It has two targets: … Read more

Lecanemab Mechanism of Action: the First Alzheimer’s Drug that Works?

Lecanemab mechanism of action

Lecanemab is an IgG1 monoclonal antibody that binds and eliminates building blocks of amyloid plaques in the brain, thus helping to slow progression of Alzheimer disease. Lacenemab: Discovery and Approval Lecanemab (brand name Leqembi) was discovered by BioArctic, a Swedish biopharmaceutical company, in collaboration with Eisai Co., Ltd. Since 2005 the team of Swedish biotech … Read more

Mechanism of Action of Nivolumab. Beating a Devil’s Advocate

Nivolumab mechanism of action

Nivolumab helps your immune system fight cancers by blocking the tumor’s ability to evade the immune response. The main target of Nivolumab (brand name is Opdivo) is the Program Death protein (PD-1). Many immune cells have this receptor, the active form of which works as a brake for an immune response. Negative Checkpoint Proteins Imagine … Read more